If you watch Soul Eater you’ll know that Asura is the main focus out of everyone else due to his legendary status. He’s evil incarnate and can easily take over whoever he wants. Asura became the very first Kishin, which means he willingly consumed a living human soul which is always a big no-no. He’s amazingly strong and consumed his very own weapon Vajra. He’s the very essence of madness in Soul Eater and is the main antagonist.
With little to no conscience, cunning skills and an insatiable want for power, Dio has the right to be on this list. He’s an immortal vampire that kicked the protagonist’s dog during his first appearance! How could you not call him a villain after hurting a poor dog?! He even slowly poisoned his own father to death over a course of five years. Now that’s evil.
I truly felt like Envy was one of the worst of the seven deadly sins in Fullmetal Alchemist. I am pretty sure that everyone would agree with me on this. Envy is the one who kills Maes Hughes and nobody will ever forgive him for that. Maes was too adorable to kill! Envy jokes around about human misery and plays with his targets before killing them. He even feels absolutely no remorse for the things he has done.